Not Just Dieting: The Best Prescription Weight Loss Treatments for Men

Paul Taylor

09 May 2025 — 2 min read

At He-MD, we offer medically supervised, evidence-based weight loss programs tailored specifically for men

Weight loss isn’t solely about willpower—it’s about understanding and leveraging biology. At He-MD, we offer medically supervised, evidence-based weight loss programs tailored specifically for men. Whether you’re grappling with stubborn weight gain, a sluggish metabolism, or low testosterone, we provide modern treatments that deliver results.

🔬 How GLP-1 Medications Work

GLP-1 receptor agonists, such as Semaglutide (Ozempic and Wegovy) and Tirzepatide (Zepbound and Mounjaro), mimic the body’s natural gut hormone GLP-1, which plays a crucial role in regulating blood sugar and appetite [1]. These medications:

Slow gastric emptying
Increase feelings of fullness
Reduce cravings and calorie intake
Improve insulin sensitivity

💊 Medications Offered by He-MD

1. Semaglutide (Ozempic and Wegovy)

Mimics GLP-1

FDA-approved for chronic weight management
Shown to reduce body weight by up to 15%

✅ Benefits: Suppresses appetite, improves glucose control

⚠️ Side effects: Nausea, diarrhea, possible constipation

2. Tirzepatide (Zepbound and Mounjaro)

Dual GLP-1 + GIP receptor agonist

Recently FDA-approved
Up to 22.5% weight loss in studies [2]

✅ Benefits: Most powerful injectable available today

⚠️ Side effects: GI upset, caution with thyroid history

3. Naltrexone/Bupropion (Contrave)

Combines craving control + mood support
Helps reduce binge eating and emotional eating

✅ Benefits: Strong mental craving control

⚠️ Side effects: Headaches, possible blood pressure increases

4. Metformin

Used off-label for weight loss
Improves insulin resistance and fat metabolism

✅ Benefits: Great for men with prediabetes or belly fat

⚠️ Side effects: Bloating, nausea (usually improves over time)

5. Topiramate

Originally for migraines/seizures
Reduces appetite + sugar cravings

✅ Benefits: Strong appetite control

⚠️ Side effects: Brain fog, tingling in fingers/toes

These medications are FDA-approved and safe when prescribed and monitored by a medical professional [3].

GLP-1 medication comparison chart

Source: People’s Pharmacy

📊 Medication Summary Table

Medication	Avg Weight Loss	Key Benefits	Common Side Effects
Semaglutide (Wegovy)	Up to 15%	Strong appetite suppression	Nausea, fatigue
Tirzepatide (Zepbound)	Up to 20%	Dual hormone action	GI upset, thyroid warning
Naltrexone/Bupropion	5–10%	Craving control + mood support	Headache, BP risk
Metformin	2–5%	Metabolism + insulin sensitivity	GI bloating
Topiramate	5–10%	Appetite suppression	Brain fog, tingling
Retatrutide (trial)	Up to 24%	Triple pathway targeting	In trials – GI focus

GLP-1 weight loss success stories for men

Source: Everyday Health

Whats Coming Next in 2025?

Orforglipron Oral GLP-1 agonist in late trials
CagriSema Combines semaglutide + amylin analog
Amycretin Dual GLP-1 and amylin receptor agonist
Retatrutide Triple hormone agonist (GLP-1, GIP, glucagon) with up to 24% weight loss